Fucidin H Special Precautions

Long-term continuous therapy with Fucidin H should be avoided. Depending on the application site, possible systemic absorption of hydrocortisone acetate should always be considered during treatment with Fucidin H.
Due to the content of corticosteroid, Fucidin H should be used with care near the eyes. Avoid getting Fucidin H into the eyes (see Adverse Reactions).
Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression may occur following systemic absorption of topical corticosteroids. Fucidin H should be used with care in children as paediatric patients may be more susceptible to topical corticosteroid-induced HPA axis suppression and Cushing's syndrome than adult patients (see Adverse Reactions).
Bacterial resistance has been reported to occur with the topical use of fusidic acid. As with all antibiotics, extended or recurrent use of fusidic acid may increase the risk of developing antibiotic resistance. Limiting therapy with topical fusidic acid and hydrocortisone acetate to no more than 14 days at a time will minimise the risk of developing resistance. This also prevents the risk that the immunosuppressive action of corticosteroid might mask any potential symptoms of infections due to antibiotic-resistant bacteria.
Due to the immunosuppressant effect of corticosteroids, Fucidin H may be associated with increased susceptibility to infection, aggravation of existing infection, and activation of latent infection. It is advised to switch to systemic therapy if infection cannot be controlled with topical treatment (see Contraindications).
Fucidin H cream contains butyl hydroxyanisole, cetyl alcohol and potassium sorbate. These excipients may cause local skin reactions (e.g. contact dermatitis). Butyl hydroxyanisole may also cause irritation to the eyes and mucous membranes.
Effects on Ability to Drive and Use Machines: Fucidin H has no or negligible influence on the ability to drive or to use machines.